Recombinant Antigens: An Introduction

3/30/2021

Proteos is an industry leader in the production of high-quality recombinant proteins for drug discovery research.  There are many variables to consider when producing recombinant proteins, and more specifically recombinant antigens.  These variables include expression system, purification techniques, protein tags, formulation, and assessment.  In the upcoming months, we will focus on specific aspects of recombinant antigen production in more detail. 

An antigen is a substance, such as a protein, that triggers an immune response resulting in antibody production. Protein antigens can be extracted from their original source for research purposes. However, these native antigens are difficult to produce in large quantities when the extraction source is in limited supply. Additionally, the purity and overall quality of native antigen preparations often varies from batch to batch.  For these reasons, producing antigens through recombinant methods is a favorable alternative to native antigen extraction. Recombinant antigen production offers a perpetual expression source, as well as convenient purification through affinity tags. With high purity and reproducibility, recombinant antigens are valuable tools for drug discovery applications, including immunoassays and antibody production.

The next blog post will focus on selecting an expression platform for recombinant antigen production.  But, if you don’t want to wait, contact us now for more information. We will guide you through the process and design a custom quotation that fits your specific project needs.

Tags: antigen, drug discovery research, expression, purification, recombinant protein production

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