November 1, 2022

Albornoz, E.A., Amarilla, A.A., Modhiran, N. et al. SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein. Mol Psychiatry (2022).

October 31, 2022

Quijano-Rubio, A., Bhuiyan, A.M., Yang, H. et al. A split, conditionally active mimetic of IL-2 reduces the toxicity of systemic cytokine therapy. Nat Biotechnol (2022).

October 22, 2022

Jeong-Yong Shin, Bina Lee, Sangwoo Ham, Ji Hun Kim, Hyojung Kim, Heejeong Kim, Min Gi Jo, Hye Jung Kim, Sang Won Park, Hee-Seok Kweon, Yong Jun Kim, Seung Pil Yun, Yunjong Lee, Pharmacological inhibition of AIMP2 aggregation attenuates α-synuclein aggregation and toxicity in Parkinson’s disease, Biomedicine & Pharmacotherapy, Volume 156, 2022, 113908, ISSN 0753-3322,

October 21, 2022

Rickner, H.D., Jiang, L., Hong, R. et al. Single cell transcriptomic profiling of a neuron-astrocyte assembloid tauopathy model. Nat Commun 13, 6275 (2022).

October 20, 2022

Lashuel, H.A., Mahul-Mellier, AL., Novello, S. et al. Revisiting the specificity and ability of phospho-S129 antibodies to capture alpha-synuclein biochemical and pathological diversity. npj Parkinsons Dis. 8, 136 (2022).

September 21, 2022

Elena Ferrari, Diego Scheggia, Elisa Zianni, Maria Italia, Marta Brumana, Luca Palazzolo, Chiara Parravicini, Andrea Pilotto, Alessandro Padovani, Elena Marcello, Ivano Eberini, Paolo Calabresi, Monica Diluca, Fabrizio Gardoni, Rabphilin-3A as a novel target to reverse α-synuclein-induced synaptic loss in Parkinson’s disease, Pharmacological Research, Volume 183, 2022, 106375, ISSN 1043-6618,

September 21, 2022

Magalhães, P., Lashuel, H.A. Opportunities and challenges of alpha-synuclein as a potential biomarker for Parkinson’s disease and other synucleinopathies. npj Parkinsons Dis. 8, 93 (2022).

September 21, 2022

Jessica Chedid, Adahir Labrador-Garrido, Siying Zhong, Jianqun Gao, Ye Zhao, Gayathri Perera, Woojin S. Kim, Glenda M. Halliday, Nicolas Dzamko,  A small molecule toll-like receptor antagonist rescues α-synuclein fibril pathology, Journal of Biological Chemistry, Volume 298, Issue 8, 2022, 102260, ISSN 0021-9258,

September 11, 2022

Genliang Liu, Zhenwei Yu, Liyan Gao, Yuanchu Zheng, Tao Feng, Erythrocytic alpha-synuclein in early Parkinson’s disease: A 3-year longitudinal study, Parkinsonism & Related Disorders, Volume 104, 2022, Pages 44-48, ISSN 1353-8020,

September 2, 2022

Chen, K., Martens, Y.A., Meneses, A. et al. LRP1 is a neuronal receptor for α-synuclein uptake and spread. Mol Neurodegeneration 17, 57 (2022).

August 8, 2022

Imarisio A, Ferrari E, Pilotto A, Di Luca M, Padovani A, Gardoni F: Synaptic Neurofilaments and GluN1-Neurofilament Light Chain Interaction in Experimental Models of α-Synucleinopathies. Neurodegener Dis 2022. doi: 10.1159/000526376

July 5, 2022

Chen M, Vincent J, Ezeanii A, Wakade S, Yerigenahally S, Mor DE. Heparan sulfate proteoglycans mediate prion-like α-synuclein toxicity in Parkinson’s in vivo models. Life Sci Alliance. 2022 Jul 5;5(11): e202201366. doi: 10.26508/lsa.202201366. PMID: 35790300; PMCID: PMC9259873.

December 21, 2018

Cao Z, Wu Y, Liu G, Jiang Y, Wang X, Wang Z, Zhang J, Feng T. α-Synuclein in salivary extracellular vesicles as a potential biomarker of Parkinson’s disease.  Neurosci Lett.

2018 Dec 21;696:114-120. doi: 10.1016/j.neulet.2018.12.030. [Epub ahead of print] PubMed PMID: 30579996.

September 11, 2018

Liu G, Tian C, Gao L, Cao Z, Feng T. Alpha-synuclein in erythrocyte membrane of patients with multiple system atrophy: A pilot study. Parkinsonism Relat Disord.

2018 Sep 11. pii: S1353-8020(18)30397-3. doi: 10.1016/j.parkreldis.2018.09.012. [Epub ahead of print] PubMed PMID: 30228038.

September 5, 2018

Zhao Y, Keshiya S, Atashrazm F, Gao J, Ittner LM, Alessi DR, Halliday GM, Fu Y, Dzamko N. Nigrostriatal pathology with reduced astrocytes in LRRK2 S910/S935 phosphorylation deficient knockin mice. Neurobiol Dis.

2018 Dec;120:76-87. doi: 10.1016/j.nbd.2018.09.003. Epub 2018 Sep 5. PubMed PMID: 30194047; PubMed Central PMCID: PMC6197399.

August 14, 2018

Zhang C, Xu Y, Chowdhary A, Fox D 3rd, Gurney ME, Zhang HT, Auerbach BD, Salvi RJ, Yang M, Li G, O’Donnell JM. Memory enhancing effects of BPN14770, an allosteric inhibitor of phosphodiesterase-4D, in wild-type and humanized mice. Neuropsychopharmacology.

2018 Oct;43(11):2299-2309. doi: 10.1038/s41386-018-0178-6. Epub 2018 Aug 14. PubMed PMID: 30131563; PubMed Central PMCID: PMC6135860.

July 26, 2018

Milanese C, Cerri S, Ulusoy A, Gornati SV, Plat A, Gabriels S, Blandini F, Di Monte DA, Hoeijmakers JH, Mastroberardino PG. Activation of the DNA damage response in vivo in synucleinopathy models of Parkinson’s disease. Cell Death Dis.

2018 Jul 26;9(8):818. doi: 10.1038/s41419-018-0848-7. PubMed PMID: 30050065; PubMed Central PMCID: PMC6062587.

May 3, 2018

Hinkovska-Galcheva V, Kelly R, Manthei KA, Bouley R, Yuan W, Schwendeman A, Tesmer JJG, Shayman JA. Determinants of pH profile and acyl chain selectivity in lysosomal phospholipase A(2). J Lipid Res.

2018 Jul;59(7):1205-1218. doi: 10.1194/jlr.M084012. Epub 2018 May 3. PubMed PMID: 29724779; PubMed Central PMCID: PMC6027918.

March 30, 2018

Abe A, Hiraoka M, Shayman JA, Ohguro H. A fluorometric assay for lysosomal phospholipase A2 activity using fluorescence-labeled truncated oxidized phospholipid. Anal Biochem.


2018 May 15;549:164-170. doi: 10.1016/j.ab.2018.03.024. Epub 2018 Mar 30. PubMed PMID: 29605449.

March 10, 2018

Teplyakov A, Obmolova G, Luo J, Gilliland GL. Crystal structure of B-cell co-receptor CD19 in complex with antibody B43 reveals an unexpected fold. Proteins.

2018 May;86(5):495-500. doi: 10.1002/prot.25485. Epub 2018 Mar 10. PubMed PMID: 29490423.


February 8, 2018

Oba-Yabana I, Mori T, Takahashi C, Hirose T, Ohsaki Y, Kinugasa S, Muroya Y, Sato E, Nguyen G, Piedagnel R, Ronco PM, Totsune K, Ito S. Acidic organelles mediate TGF-β1-induced cellular fibrosis via (pro)renin receptor and vacuolar ATPase trafficking in human peritoneal mesothelial cells. Sci Rep.

2018 Feb 8;8(1):2648. doi: 10.1038/s41598-018-20940-x. PubMed PMID: 29422602; PubMed Central PMCID: PMC5805675.

January 19, 2018

Polinski NK, Volpicelli-Daley LA, Sortwell CE, Luk KC, Cremades N, Gottler LM, Froula J, Duffy MF, Lee VMY, Martinez TN, Dave KD. Best Practices for Generating and Using Alpha-Synuclein Pre-Formed Fibrils to Model Parkinson’s Disease in Rodents. J Parkinsons Dis.

2018;8(2):303-322. doi: 10.3233/JPD-171248. PubMed PMID: 29400668; PubMed Central PMCID: PMC6004926.

October 12, 2017

Warmoth, M. The Effect of Targeted Vaccination Against Mycobacterium Avium ssp. Paratuberculosis (MAP) in a Multiple Sclerosis Mouse Model: Implications for Causation. bioRxiv

2017 October 12. bioRxiv 202275; doi: This article is a preprint and has not been peer-reviewed.

January 21, 2017

2017 Mar;83:92-99. doi:10.1016/j.molimm.2017.01.005. Epub 2017 Jan 21. PubMed PMID: 28119207.

Landeck N, Buck K, Kirik D. Toxic effects of human and rodent variants of alpha-synuclein in vivo. Eur J Neurosci.

December 19, 2016

Abe A, Hiraoka M, Ohguro H, Tesmer JJ, Shayman JA. Preferential hydrolysis of truncated oxidized glycerophospholipids by lysosomal phospholipase A2. J Lipid Res.

2017 Feb;58(2):339-349. doi: 10.1194/jlr.M070730. Epub 2016 Dec 19. PubMed PMID: 27993948; PubMed Central PMCID: PMC5282950.

December 16, 2016

Crimmins DL, Herries EM, Ohlendorf MF, Brada NA, Garbett NC, Zipfel GJ, Schindler SE, Ladenson JH. Double Monoclonal Immunoassay for Quantifying Human Visinin-Like Protein-1 in CSF. Clin Chem.

2017 Feb;63(2):603-604. doi: 10.1373/clinchem.2016.263236. Epub 2016 Dec 16. PubMed PMID: 27986783.

August 1, 2016

Maruyama S, Nakamura K, Papanicolaou KN, Sano S, Shimizu I, Asaumi Y, van den Hoff MJ, Ouchi N, Recchia FA, Walsh K. Follistatin-like 1 promotes cardiac fibroblast activation and protects the heart from rupture. EMBO Mol Med.

2016 Aug 1;8(8):949-66. doi: 10.15252/emmm.201506151. Print 2016 Aug. PubMed PMID:27234440; PubMed Central PMCID: PMC4967946.

June 22, 2016

Curtis RC, Custis JT, Ehrhart NP, Ehrhart EJ, Condon KW, Gookin SE, Donahue SW. Combination Therapy with Zoledronic Acid and Parathyroid Hormone Improves Bone Architecture and Strength following a Clinically-Relevant Dose of Stereotactic Radiation Therapy for the Local Treatment of Canine Osteosarcoma in Athymic Rats. PLoS One.

2016 Jun 22;11(6):e0158005. doi: 10.1371/journal.pone.0158005. eCollection 2016. PubMed PMID: 27332712; PubMed Central PMCID: PMC4917251.

March 2, 2015

Glukhova A, Hinkovska-Galcheva V, Kelly R, Abe A, Shayman JA, Tesmer JJ. Structure and function of lysosomal phospholipase A2 and lecithin:cholesterol acyltransferase. Nat Commun. 2015 Mar 2;6:6250. doi: 10.1038/ncomms7250. PubMed PMID: 25727495; PubMed Central PMCID: PMC4397983.

July 25, 2014

Grädler U, Czodrowski P, Tsaklakidis C, Klein M, Werkmann D, Lindemann S, Maskos K, Leuthner B. Structure-based optimization of non-peptidic Cathepsin D inhibitors. Bioorg Med Chem Lett.

2014 Sep 1;24(17):4141-50. doi: 10.1016/j.bmcl.2014.07.054. Epub 2014 Jul 25. PubMed PMID: 25086681.

February 24, 2014

McAvoy T, Lassman ME, Spellman DS, Ke z, Howell BJ, Wong O, Zhu L, Tanen M, Struyk A, Laterza OF.  Quantification of tau in cerebrospinal fluid by immunoaffinity enrichment and tandem mass spectrometry.  Clin Chem.

2014 Apr;60(4):683-9. doi: 10.1373/clinchem.2013.216515.  Epub 2014 Feb24. PubMed PMID:24566260.

November 15, 2013

Mondal K, Regnstrom K, Morishige W, Barbour R, Probst G, Xu YZ, Artis DR, Yao N, Beroza P, Bova MP. Thermodynamic and kinetic characterization of hydroxyethylamine β-secretase-1 inhibitors. Biochem Biophys Res Commun.

2013 Nov 15;441(2):291-6. doi: 10.1016/j.bbrc.2013.09.081. Epub 2013 Sep 23. PubMed PMID: 24070613.

March 29, 2013

Ren Z, Tam D, Xu YZ, Wone D, Yuan S, Sham HL, Cheung H, Regnstrom K, Chen X, Rudolph D, Jobling MF, Artis DR, Bova MP. Development of a novel β-secretase binding assay using the AlphaScreen platform. J Biomol Screen.

2013 Jul;18(6):695-704. doi: 10.1177/1087057113482138. Epub 2013 Mar 29. PubMed PMID: 23543430.

November 9, 2012

Abe A, Rzepecki PW, Shayman JA. A fluorogenic phospholipid for the detection of lysosomal phospholipase A2 activity.  Anal Biochem.

2013 Mar 1;434(1):78-83. doi: 10.1016/j.ab2012.11.004. Epub 2012 nov 9. PubMed PMID: 23146589; PubMed Central PMCID: PM3557754.

August 15, 2012

Zhang J, Preda DV, Vasquez KO, Morin J, Delaney J, Bao B, Percival MD, Xu D, McKay D, Klimas M, Bednar B, Sur C, Gao DZ, Madden K, Yared W, Rajopadhye M, Peterson JD. A fluorogenic near-infrared imaging agent for quantifying plasma and local tissue renin activity in vivo and ex vivo. Am J Physiol Renal Physiol.

2012 Aug 15;303(4):F593-603. doi: 10.1152/ajprenal.00361.2011. Epub 2012 Jun 6. PubMed PMID: 22674025; PubMed Central PMCID: PMC3423114.

May 11, 2012

Gray SK, McGee-Lawrence ME, Sanders JL, Condon KW, Tsai CJ, Donahue SW. Black  bear parathyroid hormone has greater anabolic effects on trabecular bone in dystrophin-deficient mice than in wild type mice. Bone.

2012 Sep;51(3):578-85. doi: 10.1016/j.bone.2012.05.003. Epub 2012 May 11. PubMed PMID: 22584007; PubMed Central PMCID: PMC3412940.

March 27, 2012

Duong YT, Qiu M, De AK, Jackson K, Dobbs T, Kim AA, Nkengasong JN, Parekh BS. Detection of recent HIV-1 infection using a new limiting-antigen avidity assay: potential for HIV-1 incidence estimates and avidity maturation studies. PLoS One.

2012;7(3):e33328. doi: 10.1371/journal.pone.0033328. Epub 2012 Mar 27. PubMed PMID: 22479384; PubMed Central PMCID: PMC3314002.

March 11, 2012

Fournier PA, Arbour M, Cauchon E, Chen A, Chefson A, Ducharme Y, Falgueyret JP, Gagné S, Grimm E, Han Y, Houle R, Lacombe P, Lévesque JF, MacDonald D, Mackay B, McKay D, Percival MD, Ramtohul Y, St-Jacques R, Toulmond S. Design and synthesis of potent, isoxazole-containing renin inhibitors. Bioorg Med Chem Lett.

2012 Apr 15;22(8):2670-4. doi: 10.1016/j.bmcl.2012.03.014. Epub 2012 Mar 11. PubMed PMID: 22450130.

January 26, 2012

Lacombe P, Arbour M, Aspiotis R, Cauchon E, Chen A, Dubé D, Falgueyret JP, Fournier PA, Gallant M, Grimm E, Han Y, Juteau H, Liu S, Mellon C, Ramtohul Y, Simard D, St-Jacques R, Tsui GC. 3,4-Diarylpiperidines as potent renin inhibitors. Bioorg Med Chem Lett.

2012 Mar 1;22(5):1953-7. doi: 10.1016/j.bmcl.2012.01.044. Epub 2012 Jan 26. PubMed PMID: 22325946.

December 23, 2011

Gossas T, Vrang L, Henderson I, Sedig S, Sahlberg C, Lindström E, Danielson UH. Aliskiren displays long-lasting interactions with human renin. Naunyn Schmiedebergs Arch Pharmacol.

2012 Feb;385(2):219-24. doi: 10.1007/s00210-011-0718-7. Epub 2011 Dec 23. PubMed PMID: 22193701.

December 15, 2011

Chen A, Aspiotis R, Campeau LC, Cauchon E, Chefson A, Ducharme Y, Falgueyret JP, Gagné S, Han Y, Houle R, Laliberté S, Larouche G, Lévesque JF, McKay D, Percival D. Renin inhibitors for the treatment of hypertension: design and optimization of a novel series of spirocyclic piperidines. Bioorg Med Chem Lett.

2011 Dec 15;21(24):7399-404. doi: 10.1016/j.bmcl.2011.10.013. Epub 2011 Oct 19. PubMed PMID: 22071301.

November 1, 2011

Krop M, van Gool JM, Day D, Hollenberg NK, Jan Danser AH. Evaluation of a direct prorenin assay making use of a monoclonal antibody directed against residues 32-39 of the prosegment. J Hypertens.

2011 Nov;29(11):2138-46. doi: 10.1097/HJH.0b013e32834b1978. PubMed PMID: 21881521.

October 1, 2011

Malia TJ, Obmolova G, Luo J, Teplyakov A, Sweet R, Gilliland GL. Crystallization of a challenging antigen-antibody complex: TLR3 ECD with three noncompeting Fabs. Acta Crystallogr Sect F Struct Biol Cryst Commun.

2011 Oct 1;67(Pt 10):1290-5. doi: 10.1107/S1744309111030983. Epub 2011 Sep 30. PubMed PMID: 22102050; PubMed Central PMCID: PMC3212385.

March 16, 2011

Clavreul N, Sansilvestri-Morel P, Magard D, Verbeuren TJ, Rupin A. (Pro)renin promotes fibrosis gene expression in HEK cells through a Nox4-dependent mechanism. Am J Physiol Renal Physiol.

2011 Jun;300(6):F1310-8. doi: 10.1152/ajprenal.00119.2010. Epub 2011 Mar 16. PubMed PMID: 21411480.

April 21, 2010

Abe A, Kelly R, Shayman JA. The measurement of lysosomal phospholipase A2 activity in plasma. J Lipid Res.

2010 Aug;51(8):2464-70. doi: 10.1194/jlr.D007146. Epub 2010 Apr 21. PubMed PMID: 20410020; PubMed Central PMCID: PMC2903829.

May 19, 2009

Melnyk RA, Tam J, Boie Y, Kennedy BP, Percival MD. Renin and prorenin activate pathways implicated in organ damage in human mesangial cells independent of angiotensin II production. Am J Nephrol.

2009;30(3):232-43. doi: 10.1159/000220260. Epub 2009 May 19. PubMed PMID: 19451703.

April 20, 2009

Cousin C, Bracquart D, Contrepas A, Corvol P, Muller L, Nguyen G. Soluble form of the (pro)renin receptor generated by intracellular cleavage by furin is secreted in plasma. Hypertension.

2009 Jun;53(6):1077-82. doi: 10.1161/HYPERTENSIONAHA.108.127258. Epub 2009 Apr 20. PubMed PMID: 19380613.

March 25, 2009

Abe A, Shayman JA. The role of negatively charged lipids in lysosomal phospholipase A2 function. J Lipid Res.

2009 Oct;50(10):2027-35. doi: 10.1194/jlr.M900008-JLR200. Epub 2009 Mar 25. PubMed PMID: 19321879; PubMed Central PMCID: PMC2739751.

March 1, 2009

Cauchon E, Liu S, Percival MD, Rowland SE, Xu D, Binkert C, Strickner P, Falgueyret JP. Development of a homogeneous immunoassay for the detection of angiotensin I in plasma using AlphaLISA acceptor beads technology. Anal Biochem.

2009 May 1;388(1):134-9. doi: 10.1016/j.ab.2009.02.031. Epub 2009 Mar 1. PubMed PMID: 19258005.

January 1, 2009

Slon-Usakiewicz JJ, Redden P. Application of frontal affinity chromatography with mass spectrometry (FAC-MS) for stereospecific ligand-macromolecule interaction, detection and screening. Methods Mol Biol.

2009;572:219-30. doi: 10.1007/978-1-60761-244-5_14. PubMed PMID: 20694695.