Best Practices for Novel Recombinant Protein Production

Proteos scientist working in cell culture biosafety cabinet

Proteos is an industry leader in the production of high-quality recombinant proteins for drug discovery research.  There are many variables to consider when producing novel recombinant proteins.  These variables include selection of an expression system, construct design, and scale.  In the upcoming months, we will focus on specific aspects of novel recombinant protein production in more detail. 

When producing a recombinant protein for the first time, it is wise to begin with a pilot experiment. Pilot experiments provide valuable insight for the optimal construct design, expression conditions, and purification scheme for the protein of interest. Planning for a pilot experiment requires some forethought, but it mitigates risk, cost, and time investment in the long-term. Following these best practices for pilot production can improve yield, solubility, and functionality of the recombinant protein during large-scale production.

The next blog post will focus on selecting an expression system based on protein complexity and downstream use.  But, if you don’t want to wait, contact us now for more information. We will guide you through the process and design a custom quotation that fits your specific project needs.

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