The Michael J. Fox Foundation (MJFF) Partnership
The Michael J. Fox Foundation (MJFF) is dedicated to finding a cure for Parkinson's disease (PD) through an aggressively funded research agenda to ensure the development of improved therapies for those living with Parkinson's today.
The Foundation recognizes the utility of standardized protein reagents as critical for a number of applications, including for use as standards in assays. Given this need, MJFF is working to generate a number of reagents around key PD targets.
Proteos has proudly partnered with The Michael J. Fox Foundation to provide high-quality protein reagents to support Parkinson’s disease research. The following reagents are made available to researchers for a small fee thanks to the generosity and involvement of MJFF.
To contact the Michael J. Fox Foundation directly, call 1(800)708-7644 or visit https://www.michaeljfox.org/.
To order any of the following items, click here or visit our order page.
The Research Tools generously made available through funding from the MJFF include:
Human Alpha-synuclein monomer:
Full-Length human alpha-synuclein monomeric protein generated in vitro. This protein was used to generate alpha-synuclein filament which was then used as antigen for the MJF-14 alpha-synuclein filament-specific antibody available from Abcam (ab209538).
Human Alpha-synuclein monomer to generate preformed fibrils:
Full-Length human alpha-synuclein monomeric protein specially formulated to generate pre-formed fibrils.
Polinski NK, Volpicelli-Daley LA, Sortwell CE, et al. Best Practices for Generating and Using Alpha-Synuclein Pre-Formed Fibrils to Model Parkinson’s Disease in Rodents. Journal of Parkinson’s disease. 2018;8(2):303-322. doi:10.3233/JPD-171248.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004926/pdf/jpd-8-jpd171248.pdf
Aliquots are available in 1 mg increments up to 10. Requests above 10 mg total per protein in a single order will not be considered. Questions about this limit can be directed to tools@michaeljfox.org.
Mouse Alpha-synuclein monomer to generate preformed fibrils:
Full-Length mouse alpha-synuclein monomeric protein specially formulated to generate pre-formed fibrils.
Polinski NK, Volpicelli-Daley LA, Sortwell CE, et al. Best Practices for Generating and Using Alpha-Synuclein Pre-Formed Fibrils to Model Parkinson’s Disease in Rodents. Journal of Parkinson’s disease. 2018;8(2):303-322. doi:10.3233/JPD-171248.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004926/pdf/jpd-8-jpd171248.pdf
Aliquots are available in 1 mg increments up to 10. Requests above 10 mg total per protein in a single order will not be considered. Questions about this limit can be directed to tools@michaeljfox.org.
Human Alpha-synuclein phospho-Ser129 peptide:
Phospho-S129 Alpha Synuclein semi-synthetic phosphomimetic peptide generated by native chemical ligation of a recombinant peptide produced from E. coli and a synthtic peptide.
DJ-1 proteins (E. coli):
The following versions of recombinant DJ-1 protein generated using an E. coli expression system are available:
- Untagged DJ-1
- His-tagged DJ-1
DJ-1 proteins (Mammalian):
The following versions of recombinant DJ-1 protein generated using a mammalian-optimized expression system are available:
- His-tagged DJ-1
- TEV-cleaved DJ-1